ADE 4.x crashes when opening EPUB files, but ADE 3 works fine

I'm able to open PDFs fine with ADE 4.x (4.0.3 and 4.5), but whenever I try to open any of my EPUB files, ADE crashes.  I can read those same EPUBs with Calibre just fine.  I tried uninstalling and reinstalling several times, as well as rebooting.  Nothing worked, until I uninstalled ADE 4.x and installed ADE 3 (3.0.1.91394).  Now I can read both EPUBs and PDFs just fine.

I'm running Windows 10.  Any idea why ADE 3 could be working on my PC with EPUBs, but ADE 4 doesn't?

Thanks,

Ari